Peer-reviewed veterinary case report
How MIB-1 testing predicts behavior of dog skin melanoma tumors
By Laprie, C et al.·Published in Veterinary dermatology·2001·Unité, France·View original on PubMed →
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Original publication title: MIB-1 immunoreactivity correlates with biologic behaviour in canine cutaneous melanoma.
- Species:
- dog
Plain-English summary
A study looked at 68 dogs with skin tumors called cutaneous melanomas to see how the growth of cancer cells affected their survival. The researchers found that tumors with a high growth rate (more than 15% of cells dividing) were linked to a much lower chance of surviving for two years compared to those with a low growth rate. This means that measuring the growth rate of the tumor can give vets important information about how aggressive the cancer is and what the likely outcome will be. The findings suggest that this test could be more reliable than traditional methods for predicting survival in dogs with these tumors.
People also search for: dog skin tumor survival rate · canine melanoma treatment options · what to expect with dog melanoma
Abstract
The growth fraction of 68 canine cutaneous melanomas was determined by immunostaining with MIB-1, a monoclonal antibody to a Ki-67 epitope that recognizes all proliferating cells. Fifty tumours were classified histologically as benign and 18 as malignant. The Ki-67 proliferative index (percentage of positive cells over 500 neoplastic cells) was low (< 15%) in 55 cases and high (> or = 15%) in 13 cases. High Ki-67 proliferative index and histological malignancy were both associated with significantly poorer 2-year survival (P < 0.0001). However, the predictive value of the Ki-67 proliferative index (97%) was higher than the predictive value of classical histology (91%). The evaluation of the growth fraction by the Ki-67 proliferative index is highly predictive of the biological behaviour of canine cutaneous melanoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11420929/