Peer-reviewed veterinary case report
Miniature Australian Shepherd seizuring after milbemycinoxime overdose
By Burkhardt, W et al.·Published in Schweizer Archiv fur Tierheilkunde·2012·Klinik fü·View original on PubMed →
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Original publication title: [Milbemycinoxime intoxication in a Miniature Australian Shepherd dog].
- Species:
- dog
Plain-English summary
A 3-year-old female Miniature Australian Shepherd had severe seizures after receiving a standard dose of milbemycinoxime, a medication usually considered safe for dogs with a specific genetic mutation (MDR1). She required emergency treatment, including ventilation for 36 hours due to pneumonia caused by inhaling food or liquid. After five days of intensive care and medication to control her seizures, she made a full recovery by day ten. This case highlights the need for caution when using milbemycinoxime in dogs with the MDR1 mutation, suggesting that lower doses may be safer.
People also search for: Miniature Australian Shepherd seizure treatment · milbemycinoxime side effects · dog MDR1 gene mutation risks
Abstract
A 3-year-old female intact Miniature Australian Shepherd presented with convulsive status epilepticus after milbemycinoxime administration in the recommended dosage. In addition to continuous intravenous antiepileptic therapy the dog had to be ventilated for 36 hours due to aspiration pneumonia. After extubation control of intermittent tonic-clonic seizures required a constant-rate-infusion of propofol for another 96 hours, before it could be discontinued on day 5. The patient had fully recovered by day 10. The dog was known to be homozygous for the MDR1-gene mutation. So far milbemycinoxime was regarded a save drug in MDR1-deficient dogs. However, the present case suggests using the lowest possible dosage in MDR1-deficient dogs and pet owners should be advised of potential complications.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22851434/