Peer-reviewed veterinary case report
Mild hypothermia reduces kidney damage in dogs with ARDS
By Xia, Jingen et al.·Published in Injury·2016·Department of Respiratory and Critical Care Medicine, Japan·View original on PubMed →
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Original publication title: Mild hypothermia attenuate kidney injury in canines with oleic acid-induced acute respiratory distress syndrome.
- Species:
- dog
Plain-English summary
A group of dogs with acute respiratory distress syndrome (ARDS) caused by oleic acid showed signs of kidney injury. Researchers tested whether mild hypothermia (cooling the dogs' body temperature) could help protect the kidneys. The dogs that were cooled had lower levels of kidney injury markers and less damage to their kidneys compared to those kept at normal temperature. This suggests that mild hypothermia may be a beneficial treatment for reducing kidney damage in dogs suffering from ARDS.
People also search for: dog kidney injury treatment · hypothermia for dogs with ARDS · acute respiratory distress syndrome in dogs
Abstract
BACKGROUND: Hypothermia may attenuate ventilator induced-lung injury in acute respiratory distress syndrome (ARDS). However, the impact of hypothermia on extra-pulmonary organ injury in ARDS remains unclear. The purpose of this study was to investigate whether hypothermia affects extra-pulmonary organ injury in a canine ARDS model induced by oleic acid. OBJECTIVES: Twelve anesthetized canines with oleic acid-induced ARDS were randomly divided (n=6 per group) into a hypothermia group (core temperature of 33±1°C, HT group) and a normothermia group (core temperature of 38±1°C, NT group) and treated for four hours. The liver, small intestine and kidney were assessed by evaluating biochemical parameters, plasma and tissue cytokine levels, and tissue histopathological injury scores. RESULTS: The HT group showed a lower plateau pressure, lung elastance and pulmonary vascular resistance. Hypothermia was associated with lower oxygen consumption (138.4±55.0mlmin(-1)vs. 72.0±11.2mlmin(-1), P<0.05) and higher oxygen saturation of mixed venous blood (62.8%±8.0% vs. 77.5%±10.1%, P<0.05). Both groups had similar levels of tumour necrosis factor-α in the plasma and extra-pulmonary organ, however, plasma interleukin-10 (97.1±25.0pgml(-1)vs. 131.4±27.0pgml(-1), P<0.05) was higher in the HT group. Further, the animals in the HT group had a lower levels of plasma creatinine (54.6±19.1UL(-1)vs. 29.1±8.0UL(-1), P<0.05), and lower renal histopathological injury scores [4.0(3.5;7.0) vs. 1.5(0.8;3.0), P<0.05]. Hypothermia did not affect the histopathological injury of the liver and small intestine. CONCLUSIONS: Short-term mild hypothermia can reduce lung elastance and pulmonary vascular resistance, increase the systemic anti-inflammatory response and attenuate kidney histopathological injury in a canine ARDS model induced by oleic acid.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27180146/