Peer-reviewed veterinary case report
Dog with Addison's disease showing low mineralocorticoid before low
By McGonigle, Kathryn M et al.·Published in Journal of the American Animal Hospital Association·2013·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Mineralocorticoid before glucocorticoid deficiency in a dog with primary hypoadrenocorticism and hypothyroidism.
- Species:
- dog
Plain-English summary
A dog with Addison's disease (primary hypoadrenocorticism) showed unusual symptoms and had low levels of certain electrolytes. Initially, tests indicated normal cortisol levels, but further evaluations revealed a lack of aldosterone, a hormone that helps regulate electrolytes. The vet started mineralocorticoid replacement therapy, which quickly balanced the dog's electrolytes and improved its condition temporarily. However, six weeks later, the dog developed a deficiency in cortisol as well. The dog also had hypothyroidism, which was identified during the evaluation.
People also search for: dog Addison's disease symptoms · dog electrolyte imbalance treatment · hypothyroidism in dogs
Abstract
A dog with an unexpected presentation of primary hypoadrenocorticism was evaluated for clinical signs and electrolyte abnormalities characteristic of Addison's disease. Although the initial adrenocorticotropic hormone (ACTH) stimulation test documented serum cortisol concentrations within the reference range, subsequent assessments confirmed hypoaldosteronism. Mineralocorticoid replacement promptly normalized electrolytes and transiently improved clinical illness. Six weeks after initial ACTH stimulation testing, the dog became glucocorticoid deficient. Concurrent primary hypothyroidism was also documented. Hypoaldosteronism preceding hypocortisolemia is a unique presentation of canine Addison's disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23033468/