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Peer-reviewed veterinary case report

Mineralocorticoid before glucocorticoid deficiency in a dog with primary hypoadrenocorticism and hypothyroidism.

Journal:
Journal of the American Animal Hospital Association
Year:
2013
Authors:
McGonigle, Kathryn M et al.
Affiliation:
Department of Clinical Sciences · United States
Species:
dog

Plain-English summary

A dog was diagnosed with a rare form of Addison's disease, which is a condition where the body doesn't produce enough hormones from the adrenal glands. Initially, tests showed normal cortisol levels, but later tests revealed low levels of another hormone called aldosterone. The dog was given mineralocorticoids (hormones that help balance electrolytes) which quickly improved its electrolyte levels and made it feel a bit better. However, six weeks later, the dog started having issues with cortisol production as well. The dog also had an underactive thyroid, which is another health concern. Overall, the treatment for the low aldosterone worked temporarily, but the dog later developed another hormone deficiency.

Abstract

A dog with an unexpected presentation of primary hypoadrenocorticism was evaluated for clinical signs and electrolyte abnormalities characteristic of Addison's disease. Although the initial adrenocorticotropic hormone (ACTH) stimulation test documented serum cortisol concentrations within the reference range, subsequent assessments confirmed hypoaldosteronism. Mineralocorticoid replacement promptly normalized electrolytes and transiently improved clinical illness. Six weeks after initial ACTH stimulation testing, the dog became glucocorticoid deficient. Concurrent primary hypothyroidism was also documented. Hypoaldosteronism preceding hypocortisolemia is a unique presentation of canine Addison's disease.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/23033468/