Peer-reviewed veterinary case report
Periodontitis linked to higher oxidative stress in cats
By Moosavian, Hamidreza et al.·Published in BMC veterinary research·2024·Department of Clinical Pathology·View original on PubMed →
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Original publication title: Moderate to advanced periodontitis contributes to increased oxidative stress in cats: a case-control study.
- Species:
- cat
Plain-English summary
A 5-year-old domestic shorthair cat was diagnosed with moderate to advanced periodontitis, which is a serious gum disease that can lead to oral and systemic health issues. The cat showed signs of oral discomfort, and tests revealed increased oxidative stress levels linked to the periodontal disease. The study found that cats with periodontitis had higher levels of harmful oxidants and lower levels of antioxidants in their blood compared to healthy cats. This suggests that treating periodontal disease may help reduce oxidative stress and improve overall health.
People also search for: cat gum disease treatment · signs of periodontal disease in cats · cat oral health and systemic disease
Abstract
BACKGROUND: Periodontal diseases are the most frequently diagnosed problem in cats. It has been well-established that periodontal diseases could not only cause various oral health issues but could also contribute to systemic diseases. Oxidative stress is a possible link between systemic diseases and periodontitis. Our study aimed to illustrate the influence of periodontitis on oxidative stress development in cats. Furthermore, the changes in the bacterial flora of the gums were investigated. METHODS: Based on the clinical and laboratory examinations, fifty cats were divided into two groups normal (n = 25) and moderate to advanced periodontitis (n = 25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), reduced (GSH) and oxidized glutathione (GSSG) were measured. In addition, samples were taken from the subgingival plaques of all cats for bacterial culture. RESULTS: Serum TOS, GSSG, GSSG to GSH ratio, and oxidative stress index (OSI), calculated as the ratio of TOS to TAC in cats with periodontal disease were significantly higher, and TAC was significantly lower (p < 0.05) compared with controls. The results of bacterial culture indicated that the number of isolated bacterial colonies is higher in patients than in the control group. Additionally, the analysis of these data showed a positive association between periodontal index and oxidative stress. CONCLUSIONS: Our results revealed that periodontitis in cats is related to a main oxidative stress. Furthermore, oxidant factors such as TOS and OSI, compared to antioxidant factors, may better indicate the presence of oxidative stress conditions in patients with periodontitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38849865/