Peer-reviewed veterinary case report
Molecular types of feline mammary cancer and their clinical features
By Soares, Maria et al.·Published in Breast (Edinburgh, Scotland)·2016·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Molecular based subtyping of feline mammary carcinomas and clinicopathological characterization.
- Species:
- cat
Plain-English summary
A study of 102 cats with mammary tumors found that different types of these tumors can affect how the cat behaves and responds to treatment. The most common type was the luminal B subtype, while the luminal A subtype was linked to smaller, less aggressive tumors and had the best survival rates, averaging about 943 days. In contrast, the triple negative basal-like subtype was associated with larger, more aggressive tumors and had a much shorter survival time of around 369 days. Understanding these tumor types can help veterinarians provide better care for cats with mammary cancer.
People also search for: cat mammary tumor types · feline breast cancer survival rates · treatment for cat mammary carcinoma
Abstract
Molecular classification of feline mammary carcinomas (FMC) from which specific behavioral patterns may be estimated has potential applications in veterinary clinical practice and in comparative oncology. In this perspective, the main goal of this study was to characterize both the clinical and the pathological features of the different molecular phenotypes found in a population of FMC (n = 102), using the broadly accepted IHC-based classification established by St. Gallen International Expert Consensus panel. The luminal B/HER2-negative subtype was the most common (29.4%, 30/102) followed by luminal B/HER2-positive subtype (19.6%, 20/102), triple negative basal-like (16.7%, 17/102), luminal A (14.7%, 15/102), triple negative normal-like (12.7%, 13/102) and finally, HER2-positive subtype (6.9%, 7/102). Luminal A subtype was significantly associated with smaller tumors (p = 0.024) and with well differentiated ones (p < 0.001), contrasting with the triple negative basal-like subtype, that was associated with larger and poorly differentiated tumors (p < 0.001), and with the presence of necrotic areas in the tumoral lesion (p = 0.003). In the survival analysis, cats with Luminal A subtype presented the highest survival time (mean OS = 943.6 days) and animals with triple negative basal-like subtype exhibited the lowest survival time (OS mean = 368.9 days). Moreover, two thirds (64%, 32/50) of the queens with multiple primary tumors showed different molecular subtypes in each carcinoma, revealing that all independent lesions should be analyzed in order to improve the clinical management of animals. Finally, the similarities between the subtypes of feline mammary tumors and human breast cancer, reveal that feline can be a valuable model for comparative studies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27212699/