Peer-reviewed veterinary case report
High-grade lymphoma in dog with unusual immune cell markers
By Thomas, R et al.·Published in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2001·Genetics Section, United Kingdom·View original on PubMed →
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Original publication title: Molecular cytogenetic analysis of a novel high-grade canine T-lymphoblastic lymphoma demonstrating co-expression of CD3 and CD79a cell markers.
- Species:
- dog
Plain-English summary
A 9-year-old male collie cross retriever was brought in with a swollen lymph node near his shoulder. After examining a biopsy of the lymph node, the vet diagnosed him with high-grade T-lymphoblastic lymphoma, a type of cancer affecting the immune system. Tests showed that most of the cancer cells had markers from both B- and T-cells, which is unusual. This case highlights the complexity of canine lymphoma and the importance of advanced testing methods to understand it better. The dog’s treatment plan would typically involve chemotherapy, but the specific outcome isn't detailed here.
People also search for: dog swollen lymph node · collie lymphoma treatment · canine cancer symptoms
Abstract
We present the molecular cytogenetic analysis of a novel case of canine lymphoma, in a nine-year-old entire male collie cross retriever dog that presented with an enlarged prescapular lymph node. A diagnosis of high-grade lymphoblastic lymphoma was made by histological evaluation of fixed lymph node biopsy sections, whilst immunohistochemical analyses demonstrated co-expression of B- and T-cell antigens (CD79a and CD3) by 95% of lymphomatous cells. Comparative genomic hybridisation (CGH) analysis detected loss of dog chromosomes 11, 30 and 38 and gain of chromosome 36 within the lymphoma biopsy specimen. These findings correlated with direct cytogenetic analysis of tumour metaphases using whole chromosome paint probes representing each of these four chromosomes. This study represents the first report of the combined application of both direct and indirect cytogenetic techniques for the analysis of recurrent chromosome aberrations in canine cancer.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11778688/