Peer-reviewed veterinary case report
Ehrlichia canis infection and gene types in dogs from Thailand
By Poolsawat, Napassorn et al.·Published in Scientific reports·2023·Institute of Molecular Biosciences·View original on PubMed →
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Original publication title: Molecular occurrence and genetic diversity of Ehrlichia canis in naturally infected dogs from Thailand.
- Species:
- dog
Plain-English summary
A group of dogs in Thailand was tested for a blood infection called Ehrlichia canis, which can cause serious health issues. Out of 120 dogs, 47 were found to be infected, showing that about 39% of the tested dogs had this disease. The study also looked at how the living conditions of the dogs affected their risk of infection. Understanding the genetic diversity of the bacteria can help veterinarians and pet owners better manage and prevent this infection in dogs.
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Abstract
Canine monocytic ehrlichiosis is cause by Ehrlichia canis resulting in hematologic disorders and severe clinical signs. The aim of this study was to scrutinize the molecular detection and genetic diversity of E. canis based on the trp36 gene in dogs from Thailand's northern and central regions. A total of 120 dogs blood samples were amplified for trp36 gene of E. canis using the polymerase chain reaction (PCR). Forty-seven out of 120 dog blood samples (39.16%, 47/120) were positive for E. canis the trp36 DNA with 790 bp of PCR amplicon size. The factor significantly associated with E. canis infection is animal housing status (p < 0.05). Sequence and phylogenetic analysis showed that E. canis trp36 gene of Thailand isolates was clustered into 1st clade with similarity ranging from 95.65 to 100% together with the US genogroup. The 14 haplotypes of the trp36 gene shown in TCS network exhibited that haplotype #1-4 was found in Thailand. The entropy analysis of the trp36 gene illustrated 751 polymorphic sites and 271 entropy peaks of nucleic and amino acid sequences, respectively. Hence, these findings are crucial for better understanding the epidemiology of Ehrlichia infection and could be helpful for implementing control measures in Thailand.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37989840/