Peer-reviewed veterinary case report
Gene profiles identify key types of canine lymphoma linked to outcomes
By Frantz, A M et al.·Published in Veterinary pathology·2013·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Molecular profiling reveals prognostically significant subtypes of canine lymphoma.
- Species:
- dog
Plain-English summary
A study found that dogs with lymphoma, a type of cancer affecting the lymphatic system, can be grouped into three main types based on their genetic makeup. These types include low-grade T-cell lymphoma, high-grade T-cell lymphoma, and B-cell lymphoma. Understanding these subtypes is important because they can help predict how long a dog might live after diagnosis. Researchers also created a simple test that can identify which type of lymphoma a dog has by looking at the expression of four specific genes. This can help veterinarians choose the best treatment plan for affected dogs.
People also search for: dog lymphoma types · canine lymphoma treatment · dog cancer survival rates · what is B-cell lymphoma in dogs · lymphoma gene test for dogs
Abstract
We performed genomewide gene expression analysis of 35 samples representing 6 common histologic subtypes of canine lymphoma and bioinformatics analyses to define their molecular characteristics. Three major groups were defined on the basis of gene expression profiles: (1) low-grade T-cell lymphoma, composed entirely by T-zone lymphoma; (2) high-grade T-cell lymphoma, consisting of lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified; and (3) B-cell lymphoma, consisting of marginal B-cell lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. Interspecies comparative analyses of gene expression profiles also showed that marginal B-cell lymphoma and diffuse large B-cell lymphoma in dogs and humans might represent a continuum of disease with similar drivers. The classification of these diverse tumors into 3 subgroups was prognostically significant, as the groups were directly correlated with event-free survival. Finally, we developed a benchtop diagnostic test based on expression of 4 genes that can robustly classify canine lymphomas into one of these 3 subgroups, enabling a direct clinical application for our results.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23125145/