Peer-reviewed veterinary case report
Tracking large B-cell and T-zone lymphoma in a dog with flow cytometry
By Rosenbaum, Claire S et al.Ā·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, IncĀ·2021Ā·Department of Veterinary Clinical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Monitoring of large B-cell lymphoma and T-zone lymphoma in a dog via flow cytometry.
- Species:
- dog
Plain-English summary
A 12-year-old male Pomeranian was brought in because his lymph nodes were swollen. Tests showed he had two types of cancer: T-zone lymphoma and B-cell lymphoma. The vet started a multi-drug chemotherapy treatment, which successfully eliminated the B-cell lymphoma, but the T-zone lymphoma remained and the swollen lymph nodes did not go away. This case highlights how flow cytometry can help diagnose different types of cancer in dogs and shows that some cancers can be harder to treat than others.
People also search for: dog swollen lymph nodes Ā· Pomeranian lymphoma treatment Ā· dog chemotherapy for cancer
Abstract
A 12-y-old, castrated male Pomeranian dog was presented because of mandibular lymph node (LN) enlargement. Physical examination and a complete blood count revealed generalized lymphadenopathy and moderate lymphocytosis. Fine-needle aspirate cytology revealed expansion of medium lymphocytes in the right mandibular LN and expansion of large lymphocytes in the left popliteal LN. Flow cytometry identified 2 aberrant lymphocyte populations in both LNs, namely a CD5+CD45- T-cell population, and a large CD21+ B-cell population. Flow cytometry of the peripheral blood revealed an identical population of aberrant CD45- T cells. The patient was diagnosed with concurrent T-zone lymphoma and leukemia, and B-cell lymphoma. Multi-agent chemotherapy was instituted, and serial clinical and flow cytometric analysis revealed complete remission of the neoplastic B cells, but persistence of the neoplastic T cells and persistent lymphadenopathy. This case affirms the diagnostic value of flow cytometry and reveals a unique limitation of the RECIST criteria.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34176384/