Peer-reviewed veterinary case report
Dog leishmaniosis treatment results with four protocols over one year
By Paradies, Paola et al.·Published in Research in veterinary science·2012·Department of Public Health and Animal Sciences, Italy·View original on PubMed →
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Original publication title: Monitoring the reverse to normal of clinico-pathological findings and the disease free interval time using four different treatment protocols for canine leishmaniosis in an endemic area.
- Species:
- dog
Plain-English summary
Twenty-four dogs with leishmaniasis, a disease caused by a parasite, were treated with different medication combinations to see which worked best. Some dogs received a treatment called meglumine antimoniate alone, while others received it along with allopurinol. The dogs treated with both medications showed no relapses of the disease during a year of monitoring, while some dogs treated with just meglumine antimoniate did relapse. The combination treatment not only prevented relapses but also extended the time without disease symptoms for up to 65 months, making it the most effective option for these dogs.
People also search for: dog leishmaniasis treatment · meglumine antimoniate for dogs · allopurinol for dog parasites
Abstract
Twenty-four dogs naturally infected by Leishmania spp. were treated with four different protocols using meglumine antimoniate (aNm) and allopurinol in combination or in monotherapy. Aiming to compare the efficacy of the different treatments the reverse to normal of clinico-pathological findings and the disease free interval time (DFIT) were evaluated. Treated dogs were monitored for 1 year and, in absence of relapses, the DFIT was postponed to the last available follow-up. Seven dogs treated with aNm alone showed relapses during the year of observation. In the group of dogs treated with the combination of aNm (50 mg/kg/SC 12 hourly up to clinico-pathological recovery) and allopurinol (15 mg/kg/PO 12 hourly administered for 6months) no relapses were registered in the year of monitoring and the DFIT reached up to 65 months. Our results showed that this combination represents the best choice to treat canine leishmaniosis compared to other protocols.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22296941/