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Peer-reviewed veterinary case report

Monkeypox Virus Cross-Neutralizing Antibodies in Clinical Trial Participants Vaccinated With Modified Vaccinia Virus Ankara Encoding Middle East Respiratory Syndrome-Coronavirus Spike Protein.

Journal:
The Journal of infectious diseases
Year:
2023
Authors:
Raadsen, Matthijs P et al.
Affiliation:
Department of Viroscience · Netherlands

Abstract

Modified vaccinia virus Ankara (MVA) is used as a vaccine against monkeypox virus and as a viral vaccine vector. MVA-MERS-S is a vaccine candidate against Middle East respiratory syndrome (MERS)-associated coronavirus. Here, we report that cross-reactive monkeypox virus neutralizing antibodies were detectable in only a single study participant after the first dose of MVA-MERS-S vaccine, in 3 of 10 after the second dose, and in 10 of 10 after the third dose.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/36857443/