Peer-reviewed veterinary case report
Monoclonal gammopathies in dogs linked to tumors and infections
By Giraudel, Jérĵme M et al.·Published in Journal of the American Animal Hospital Association·2002·Department of Small Animal Clinical Sciences, France·View original on PubMed →
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Original publication title: Monoclonal gammopathies in the dog: a retrospective study of 18 cases (1986-1999) and literature review.
- Species:
- dog
Plain-English summary
Eighteen dogs were diagnosed with monoclonal gammopathies, a condition where abnormal proteins are produced, often linked to certain types of cancer. Many of these dogs showed symptoms like weakness or bleeding issues, and tests revealed problems such as protein in the urine, low protein levels in the blood, and anemia. The most common underlying issues included multiple myeloma and other blood-related cancers. Treatment varied depending on the specific diagnosis, but the study highlights the importance of recognizing these symptoms and getting a thorough evaluation from a veterinarian.
Abstract
Eighteen dogs with monoclonal gammopathies were evaluated retrospectively. Most of the cases were associated with lymphoproliferative tumors (i.e., nine multiple myelomas, one Waldenström's macroglobulinemia, one lymphoma, one chronic lymphocytic leukemia, and one mucocutaneous plasmacytoma). The prevalence of nonmyelomatous monoclonal gammopathies (28%) was also significant (three leishmaniasis and two ehrlichiosis). Presenting complaints and clinical signs often were nonspecific or related to bleeding diathesis. Significant laboratory findings included proteinuria, hypoalbuminemia, and anemia. Some unusual features were also observed: a multiple myeloma with immunoglobulin M secretion, another myeloma with two narrow spikes on the electrophoretic pattern, and a mucocutaneous plasmacytoma secreting an immunoglobulin G paraprotein.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11908831/