Peer-reviewed veterinary case report
Monoclonal gammopathy in 2 dogs without high globulin levels
By Seelig, Davis M et al.·Published in Veterinary clinical pathology·2010·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Monoclonal gammopathy without hyperglobulinemia in 2 dogs with IgA secretory neoplasms.
- Species:
- dog
Plain-English summary
An 8.5-year-old male Golden Retriever and a 10-year-old female English Springer Spaniel were brought to the vet for serious health issues: one had high calcium levels and the other had severe anemia. Tests showed that both dogs had unusual lymphoid cells in their bone marrow, leading to a diagnosis of IgA secretory neoplasms, a type of cancer affecting their immune cells. Despite not having the typical signs of high protein levels in their blood, the dogs were found to have a specific type of cancer that required careful management. The findings highlight the importance of thorough testing for certain cancers in dogs, even when common symptoms are absent.
People also search for: dog cancer symptoms · Golden Retriever high calcium treatment · Springer Spaniel anemia diagnosis
Abstract
Two dogs, an 8.5-year-old intact male Golden Retriever and a 10-year-old spayed female English Springer Spaniel, each with varied clinical histories, were referred to the Colorado State University Veterinary Teaching Hospital for evaluation of hypercalcemia and severe anemia, respectively. In each dog, serum total protein and globulin concentrations were within reference intervals. Cytologic examination of bone marrow aspirates from both dogs revealed moderate to marked numbers of atypical lymphoid cells with plasma cell features. Using serum immunofixation and serum immunoglobulin (Ig) quantification, a monoclonal Ig protein was identified. In conjunction with other clinicopathologic and molecular findings, IgA secretory neoplasms, B-cell lymphoma with plasmacytoid features and multiple myeloma (MM), were diagnosed. To our knowledge, these cases represent the first descriptions of IgA-secreting neoplasms in dogs that lacked hyperglobulinemia. In cases of suspected B-cell lymphoma or MM in dogs, serum proteins should be fully evaluated for the presence of a monoclonal Ig even in dogs that lack characteristic hyperproteinemia or hyperglobulinemia. This evaluation will aid in the diagnosis of secretory B-cell lymphoma or MM leading to appropriate clinical and therapeutic case management.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20969607/