Peer-reviewed veterinary case report
Cat with right hind leg lameness diagnosed with synovial cell sarcoma
By Cazzini, Paola et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2015·Sakamoto) College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Morphologic, molecular, and ultrastructural characterization of a feline synovial cell sarcoma and derived cell line.
- Species:
- cat
Plain-English summary
A 2.5-year-old male cat was brought in due to a 5-month history of limping on his right hind leg and an enlarged lymph node behind his knee. X-rays showed significant bone damage in his leg, and tests on the bone and lymph node revealed a tumor. The decision was made to amputate the leg, and further tests confirmed the tumor was a synovial cell sarcoma, a type of cancer affecting the connective tissue around joints. Unfortunately, the specific treatment outcomes after amputation were not detailed, but this diagnosis helps guide future care and monitoring.
People also search for: cat limping · cat leg tumor · synovial cell sarcoma in cats · cat amputation recovery
Abstract
A 2.5-year-old, male, neutered cat presented with a 5-month history of progressive right hind limb lameness and an enlarged right popliteal lymph node. Radiographs revealed significant bony lysis of the tarsus and distal tibia, and fine-needle aspirate of the bone lesion and lymph node revealed a neoplastic population of cells with uncertain origin. Amputation was elected, and the mass was submitted for histology and cellular culture for better characterization. Histologic examination revealed a mixture of spindle-shaped cells and larger, round to polygonal cells. All cells were immunoreactive for vimentin, and only the larger polygonal cells were also positive for cytokeratin. All cells were negative for desmin, smooth muscle actin, cluster of differentiation (CD)3, CD18, CD79a, macrophage antibody (MAC)387, and glial fibrillary acidic protein. Cultured neoplastic cells failed to express CD18, and were not able to secrete the pro-inflammatory cytokines tumor necrosis factor-α, interleukin-1 (IL-1)β, and IL-6 when stimulated by lipopolysaccharide, disproving that the cells originated from the macrophage or monocyte line. Ultrastructurally, neoplastic cells were characterized by abundant rough endoplasmic reticulum, interdigitating cellular processes, and membrane condensations. Based on location and cytologic, histologic, ultrastructural, and functional studies, this neoplasm was considered a synovial cell sarcoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25901004/