Peer-reviewed veterinary case report
Dog with multicentric B-cell lymphoma showing unusual Mott cell
By Woo-Sub Kim et al.·Published in Veterinary Sciences·2022·Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea, CH·View original on DOAJ →
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Original publication title: Mott Cell Differentiation in Canine Multicentric B Cell Lymphoma with Cross-Lineage Rearrangement and Lineage Infidelity in a Dog
- Species:
- dog
Plain-English summary
A 4-year-old female mongrel dog was brought in with swollen lymph nodes and an enlarged abdomen. Tests showed an increase in certain white blood cells, leading to a diagnosis of multicentric B-cell lymphoma, a type of cancer affecting the lymphatic system. Despite starting chemotherapy, the dog's condition worsened, and she sadly passed away three months later. This case highlights a rare form of lymphoma with unusual characteristics that can lead to a challenging outcome.
People also search for: dog swollen lymph nodes · lymphoma in dogs treatment · signs of dog cancer
Abstract
Lymphoma is a severe condition characterized by the proliferation of neoplastic lymphoid cells. A 4-year-old female mongrel dog presented with solitary lymph node enlargement. Significant right prescapular lymphadenopathy and abdominal enlargement were observed during physical examination. A complete blood count revealed lymphocytosis, and a peripheral blood smear revealed lymphoblastosis and Mott cells. Fine needle aspiration cytology (FNAC) of the right prescapular lymph node revealed a predominant population of lymphoblasts and Mott cells. Based on the FNAC and blood smear results, the patient was diagnosed with leukemic state multicentric B-cell lymphoma with Mott cell differentiation. Subsequent PCR for antigen receptor rearrangement and flow cytometry revealed that the patient exhibited cross-lineage rearrangement (CLRA) and lineage infidelity (LI), respectively. CHOP-based chemotherapy was initiated, however, the patient’s disease was progressive. The patient died three months after the initial presentation. Mott cell differentiation in canine B-cell lymphoma (MCL) has rarely been reported in the veterinary literature and seems to show an unusual clinical course. To the best of our knowledge, no reports of MCL with CLRA and LI exist. We report the clinical features, diagnosis, and treatment of MCL with CLRA and LI.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/vetsci9100549