Peer-reviewed veterinary case report
Dog with lymphoma and widespread skin hardening from cancer effects
By Affolter, Verena K et al.·Published in Veterinary dermatology·2020·Department of Pathology, United States·View original on PubMed →
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Original publication title: Multicentric B-cell lymphoma with presumed paraneoplastic generalized cutaneous sclerosis in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old male chihuahua-mix was brought in for severe skin problems, including hair loss and thickened skin, along with swollen lymph nodes. Tests revealed he had an intermediate to large B-cell lymphoma, a type of cancer affecting the lymphatic system. Although the lymphoma was treated, the skin issues did not improve, and sadly, the dog was euthanized due to the severity of his condition. This case highlights a rare connection between lymphoma and skin thickening in dogs.
People also search for: dog skin thickening · chihuahua lymphoma treatment · why is my dog losing hair
Abstract
BACKGROUND: Reports of dermal sclerosis in dogs include scleroderma or morphea of unknown cause, cicatricial alopecia and congenital/hereditary fibrosis. CLINICAL SUMMARY: A 12-year-old, male castrated chihuahua-mix dog was evaluated for skin lesions of unknown duration. The dog had severe alopecia, skin thickening and marked peripheral lymphadenopathy. Lymph node cytological investigation, immunohistochemical investigation and clonality testing demonstrated an intermediate to large B-cell lymphoma. The thickened skin had severe collagen deposition, effacing adnexal structures. The dog's lymphoma was treated but the skin lesions remained unchanged. The dog was euthanized. CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors' knowledge, this is the first report of multicentric B-cell lymphoma in a dog with concurrent diffuse cutaneous sclerosis, similar to a human paraneoplastic reaction.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31930629/