Peer-reviewed veterinary case report
Dog developed lymphoma after cyclosporine for anal furunculosis
By Blackwood, L et al.·Published in The Journal of small animal practice·2004·Small Animal Hospital, United Kingdom·View original on PubMed →
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Original publication title: Multicentric lymphoma in a dog after cyclosporine therapy.
- Species:
- dog
Plain-English summary
An 11-year-old neutered male German shepherd was brought in with painful sores around the anus, which were diagnosed as anal furunculosis. The vet treated him with cyclosporine and ketoconazole, and the sores healed well. However, four weeks later, the dog developed multicentric lymphoma, a type of cancer. Fortunately, he went into complete remission after receiving combination chemotherapy. While it's not certain that the cyclosporine caused the lymphoma, there may be a link, and pet owners should be aware of this potential risk when considering this medication.
People also search for: dog anal furunculosis treatment · German shepherd lymphoma symptoms · cyclosporine side effects in dogs
Abstract
An 11-year-old, neutered male German shepherd dog was presented with perianal ulceration and fistulas. A clinical diagnosis of anal furunculosis was made, and the dog was treated with cyclosporine and ketoconazole. The perianal lesions resolved. However, after four weeks of therapy the dog developed multicentric lymphoma. Complete remission was achieved with combination chemotherapy (Wisconsin-Madison protocol). Cyclosporine administration is associated with an increased risk of development of lymphoma in humans and a similar increased risk might be expected in dogs. Although a causative relationship between cyclosporine administration and the development of lymphoma cannot be proven in this case, it is possible that cyclosporine therapy may have contributed to lymphomagenesis. As the use of cyclosporine in small animals is increasing, further work is required to substantiate and quantify the proposed increased risk.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15163054/