Peer-reviewed veterinary case report
Multiple myeloma in two cats with different symptoms and treatments
By Bienzle, D et al.·Published in Veterinary pathology·2000·Department of Pathobiology, Canada·View original on PubMed →
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Original publication title: Multiple myeloma in cats: variable presentation with different immunoglobulin isotypes in two cats.
- Species:
- cat
Plain-English summary
A 10-year-old male domestic shorthair cat was diagnosed with multiple myeloma after showing signs of high protein levels in the urine and abnormal plasma cells in the bone marrow. One cat had a type of myeloma that produced immunoglobulin G and responded well to surgery, radiation, and chemotherapy, living for about two more years. The second cat had a more aggressive form that caused high calcium levels and kidney problems, but unfortunately, it did not respond to chemotherapy.
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Abstract
Multiple myeloma was diagnosed in two cats with monoclonal hyperglobulinemia, proteinuria, and plasma cell proliferations in bone marrow. An immunoglobulin G-producing myeloma occurred in the vertebral bone marrow of one cat, and twice responded to surgical reduction followed by a combination of local irradiation and chemotherapy. The cat's survival time was approximately 2 years. The other myeloma in a cat that presented with hypercalcemia and renal insufficiency involved visceral organs and produced a biclonal peak due to immunoglobulin A dimer formation on serum electrophoresis. This cat's tumor did not respond to chemotherapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10896403/