Peer-reviewed veterinary case report
English Springer Spaniel with gut multiple myeloma
By Roberts, Emma et al.·Published in Veterinary medicine and science·2022·Highcroft Veterinary Referrals, United Kingdom·View original on PubMed →
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Original publication title: Multiple myeloma involving the gastrointestinal tract in an English Springer Spaniel.
- Species:
- dog
Plain-English summary
A 10-year-old male English Springer Spaniel was brought to the vet because he was losing weight, drinking a lot, urinating frequently, and had gastrointestinal issues like bloody stools for six months. After various tests, including blood work and biopsies, he was diagnosed with multiple myeloma, a type of cancer affecting plasma cells. The dog started treatment with melphalan and prednisolone, and he went into complete remission within seven weeks. Unfortunately, he was later euthanized due to severe neck pain and collapse, but at that time, there were no signs of cancer returning.
People also search for: dog weight loss and bloody stools · English Springer Spaniel cancer treatment · multiple myeloma in dogs
Abstract
A 10-year-old, entire male, English Springer Spaniel was referred for evaluation of weight loss, polyuria, polydipsia and gastrointestinal tract signs including melena/haematochezia for the previous six months. Results of serum protein electrophoresis, urine analysis, computed tomography of the thorax/abdomen, bone marrow aspiration and core biopsy, and splenic and mesenteric lymph node cytology were consistent with multiple myeloma. Endoscopically obtained gastrointestinal tract biopsies identified marked plasma cell infiltration within the duodenum, ileum and colon; immunohistochemistry showed positive labelling to MUM1 and Lambda confirming clonal plasma cell involvement. The dog entered complete clinical remission seven weeks after starting a melphalan/prednisolone protocol. The dog was euthanised 475 days after starting treatment due to cervical pain and collapse. At the time of euthanasia, blood work was not supportive of a relapse of multiple myeloma. To the authors' knowledge, this is the first report of multiple myeloma involving the gastrointestinal tract in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36054812/