Peer-reviewed veterinary case report
Dog with multiple myeloma causing bone loss but no gammopathy
By Souchon, F et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2013·Dr. Franziska Souchon·View original on PubMed →
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Original publication title: [Multiple myeloma with significant multifocal osteolysis in a dog without a detectible gammopathy].
- Species:
- dog
Plain-English summary
A Border Collie mix was brought to the vet after showing signs of weakness in its hind legs, along with lethargy and tiredness that had developed over the past six weeks. X-rays revealed small areas of bone loss in the spine and pelvis, and further scans showed widespread bone destruction throughout the body. Blood tests indicated anemia and high calcium levels. The dog was diagnosed with a rare form of multiple myeloma, a type of cancer affecting the bone marrow, which typically does not show the usual signs of the disease. Treatment options would depend on the specific case and may include chemotherapy or supportive care.
People also search for: dog hind leg weakness · Border Collie cancer symptoms · multiple myeloma treatment in dogs
Abstract
Description of a variant of multiple myeloma in a dog lacking the gammopathy normally associated with this type of neoplasm. A Border Collie mongrel was presented with symptoms of progressive hind-leg weakness, lethargy and tiredness, which had started to appear 6 weeks previously. Radiographic examination showed small osteolytic areas in the spinal column, but also diffuse small areas of increased opacity as well as evidence of decreased bone density in the pelvis and of both femoral necks. Moderate regenerative anaemia, hypogammopathy and hypercalcaemia were diagnosed. Computed tomography scans displayed multifocal osteolysis and bone destruction in the skull, spinal column, scapulae, proximal humeri, pelvis and femoral necks. H&E staining of the biopsies showed bone destruction and monomorphic plasmacyotid cell populations, causing infiltrative bone marrow lesions and osteolysis. In many areas neoplastic plasma cell infiltration of the bone marrow was 70% and in some areas reached 100%. The diagnosis was non-secretory multiple myeloma without apparent secretion of paraproteins into the blood.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24326882/