Peer-reviewed veterinary case report
How MUM1/IRF4 helps diagnose Langerhans cell histiocytosis in dogs
By Klosowski, Marika L et al.·Published in Veterinary clinical pathology·2023·Department of Microbiology, United States·View original on PubMed →
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Original publication title: MUM1/IRF4 immunolabeling of neoplastic Langerhans histiocytes in a putative case of canine Langerhans cell histiocytosis.
- Species:
- dog
Plain-English summary
A 3-year-old male Golden Retriever was diagnosed with a rare condition called Langerhans cell histiocytosis, which involves an abnormal increase in certain immune cells and can cause skin problems. The dog underwent a thorough examination that included various tests to confirm the diagnosis. The findings showed that the dog's condition had similarities to a similar disease seen in humans. Although this case is unique, it highlights the importance of proper diagnosis and understanding of this condition in dogs.
People also search for: Golden Retriever skin problems · dog Langerhans cell histiocytosis · canine histiocytic disease treatment
Abstract
Langerhans cell histiocytosis is a systemic histiocytic proliferative disease with cutaneous manifestations which is well described in human medical literature and has relatively recently been reclassified as a neoplastic disorder. The diagnosis of canine Langerhans cell histiocytosis has been proposed in the veterinary literature to refer to a histiocytic proliferative disease in the dog with clinical and histopathologic features that mirror the human disease. However, reports that invoke this diagnosis are rare and often lack complete diagnostic characterization. This case report presents an extensive diagnostic investigation of a putative case of Langerhans cell histiocytosis in a 3-year-old male castrated Golden Retriever dog, including gross, cytologic, histopathologic, and immunohistochemical findings. Furthermore, we document that canine LCH may have positive immunolabeling for the transcription factor multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF4), which is classically used for the diagnosis of canine plasma cell neoplasms.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37528067/