Peer-reviewed veterinary case report
How a rare skin cancer was diagnosed in a young Golden Retriever
By Marika L Klosowski et al.·Published in Veterinary clinical pathology·2023·View original on Semantic Scholar →
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Original publication title: MUM1/IRF4 immunolabeling of neoplastic Langerhans histiocytes in a putative case of canine Langerhans cell histiocytosis.
- Species:
- dog
Plain-English summary
A 3-year-old male Golden Retriever was diagnosed with a rare condition called Langerhans cell histiocytosis, which involves an abnormal growth of certain immune cells and can cause skin problems. The dog underwent a thorough examination that included various tests to confirm the diagnosis. The findings suggested that this condition in dogs may share similarities with a similar disease in humans. While the report highlights the diagnostic process, it also notes that specific treatments for this condition were not detailed.
People also search for: Golden Retriever skin problems · dog Langerhans cell histiocytosis · canine histiocytic disease treatment
Abstract
Langerhans cell histiocytosis is a systemic histiocytic proliferative disease with cutaneous manifestations which is well described in human medical literature and has relatively recently been reclassified as a neoplastic disorder. The diagnosis of canine Langerhans cell histiocytosis has been proposed in the veterinary literature to refer to a histiocytic proliferative disease in the dog with clinical and histopathologic features that mirror the human disease. However, reports that invoke this diagnosis are rare and often lack complete diagnostic characterization. This case report presents an extensive diagnostic investigation of a putative case of Langerhans cell histiocytosis in a 3-year-old male castrated Golden Retriever dog, including gross, cytologic, histopathologic, and immunohistochemical findings. Furthermore, we document that canine LCH may have positive immunolabeling for the transcription factor multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF4), which is classically used for the diagnosis of canine plasma cell neoplasms.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/37528067