Peer-reviewed veterinary case report
Protein in urine from minimal change kidney disease in a dog
By Travail, Victoria et al.·Published in Journal of veterinary internal medicine·2022·Southern Counties Veterinary Specialists, United Kingdom·View original on PubMed →
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Original publication title: Mycophenolate mofetil and telmisartan for the treatment of proteinuria secondary to minimal change disease podocytopathy in a dog.
- Species:
- dog
Plain-English summary
A 3-year-old female Springer Spaniel was brought to the vet because she had protein in her urine, which was discovered during tests for other health issues. She also had low albumin levels and high cholesterol. After a kidney biopsy, she was diagnosed with minimal change disease, a condition affecting the kidney's filtering units. The vet treated her with two medications, telmisartan and mycophenolate mofetil, and within four weeks, her protein levels, albumin, and cholesterol returned to normal.
People also search for: dog protein in urine treatment · Springer Spaniel kidney disease · minimal change disease in dogs
Abstract
A 3-year-old entire female Springer Spaniel, with a previous diagnosis of meningoencephalitis of unknown origin diagnosed 2 years before presentation and treated with long term administration of prednisolone, developed proteinuria. Laboratory findings revealed hypoalbuminemia, hypercholesterolemia, and proteinuria. Further investigations excluded underlying causes. Renal biopsies were performed. The glomeruli and the tubulointerstitial compartment did not show any anomalies on light microscopy and immunofluorescence staining did not reveal abnormalities. Transmission electron microscopy revealed moderate podocyte injury consisting of foot process effacement and microvillus transformation of the cytoplasm. The dog was diagnosed with primary minimal change disease of the podocytes and treated with telmisartan and mycophenolate mofetil. Abnormalities of serum albumin, cholesterol, and proteinuria resolved within 4 weeks. Minimal change disease has been reported in dogs, but this is a case report of proteinuria secondary to minimal change disease successfully treated with mycophenolate mofetil and telmisartan.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36151875/