Peer-reviewed veterinary case report
Neurolymphomatosis in three horses with multicentric T-cell-rich B-cell lymphoma.
- Journal:
- Journal of comparative pathology
- Year:
- 2014
- Authors:
- Lehmbecker, A et al.
- Affiliation:
- Department of Pathology · Germany
- Species:
- horse
Plain-English summary
This study looked at three horses that had a rare type of cancer called neurolymphomatosis, which affects the nerves and is linked to multicentric T-cell-rich B-cell lymphoma, a specific form of lymphoma. In these horses, tests showed that cancer cells were invading their peripheral nerves. The findings suggest that if a horse with lymphoma is showing signs of nerve problems, this type of cancer should be considered as a possible cause. Overall, the report highlights the importance of recognizing this rare condition in horses with lymphoma.
Abstract
Neurolymphomatosis is a rare manifestation of lymphoma and is characterized by neoplastic infiltration of the peripheral nervous system. The present report describes neoplastic infiltration of peripheral nerves in three horses with multicentric lymphoma. Immunohistochemistry revealed the presence of CD79a(+) lymphoblastic cells and well-differentiated CD3(+) T cells, characteristic of T-cell-rich B-cell lymphoma in all cases. Nerve infiltration by lymphoma is rare, but should be considered as a differential diagnosis for peripheral neuropathy in horses with lymphoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24915887/