Peer-reviewed veterinary case report
Lymphoproliferative disease with features of lymphoma in the central nervous system of a horse.
- Journal:
- Journal of comparative pathology
- Year:
- 2008
- Authors:
- Morrison, L R et al.
- Affiliation:
- Royal (Dick) School of Veterinary Studies · United Kingdom
- Species:
- horse
Plain-English summary
This report discusses a rare case of lymphoma, a type of cancer, found in the brain and spinal cord of a horse in the UK. In this instance, the disease was limited to the central nervous system, meaning there were no signs of cancer elsewhere in the body. Tests showed a large number of certain immune cells called T lymphocytes, along with some B lymphocytes and activated macrophages, which are also types of immune cells. This case highlights how difficult it can be to diagnose this kind of disease in horses. The outcome of the treatment is not mentioned in the report.
Abstract
Lymphoma (malignant lymphoma, lymphosarcoma) is uncommon in horses in the United Kingdom. This report describes an unusual form of lymphoproliferative disease with features of lymphoma restricted to the central nervous system (CNS) and with no evidence of a primary lesion elsewhere. Immunohistochemical examination defined an overwhelming predominance of T lymphocytes with admixed B lymphocytes and activated macrophages. This case exemplifies the challenges associated with definitive diagnosis of lymphoproliferative disease of the equine CNS.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18823902/