Peer-reviewed veterinary case report
NGAL levels in dogs with kidney disease, cancer, and endotoxaemia
By Cobrin, A R et al.·Published in The Journal of small animal practice·2016·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Neutrophil gelatinase-associated lipocalin in dogs with chronic kidney disease, carcinoma, lymphoma and endotoxaemia.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease, cancer, or severe infections were tested for a protein called NGAL, which can indicate kidney problems. The study found that dogs with chronic kidney disease had higher levels of NGAL in their blood and urine compared to healthy dogs. However, the NGAL levels did not change significantly over six months in dogs with stable chronic kidney disease. This suggests that while NGAL can be a marker for kidney issues, more research is needed to see if it can help diagnose chronic kidney disease more accurately than other tests.
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Abstract
OBJECTIVES: To measure serum and urine neutrophil gelatinase-associated lipocalin (NGAL) concentrations in healthy dogs and dogs with chronic kidney disease, neoplasia and endotoxaemia. METHODS: Serum and urine NGAL concentrations were measured in 42 healthy dogs, 11 dogs with chronic kidney disease, 12 dogs with carcinoma, 20 dogs with lymphoma and 15 dogs with lipopolysaccharide-induced endotoxaemia. In dogs with chronic kidney disease, NGAL was measured 3 and 6 months later. RESULTS: Compared with healthy controls, dogs with chronic kidney disease (PÄ0·0008), carcinoma (PÄ0·0072) and lymphoma (PÄ0·0008) had elevated serum and urine NGAL and urine NGAL-to-creatinine ratio. Serum and urine NGAL was not significantly different between dogs with chronic kidney disease, carcinoma or lymphoma (Pê0·12). In dogs with non-progressive chronic kidney disease, NGAL concentrations did not change significantly over the 6-month study period. CLINICAL SIGNIFICANCE: NGAL can be elevated by chronic kidney disease and neoplasia, compared with healthy controls. Further research is needed to determine if uNGAL or uNGAL-to-creatinine ratio is more specific than serum levels to detect chronic kidney disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27112380/