Peer-reviewed veterinary case report
12-Year-Old Beagle with Multiple Skin Lumps
By Maria Teresa Antognoni et al.·Published in Veterinary Sciences·2021·Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06124 Perugia, Italy, CH·View original on DOAJ →
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Original publication title: Non Epitheliotropic B-Cell Lymphoma with Plasmablastic Differentiation vs. Cutaneous Plasmacytosis in a 12-Years-Old Beagle: Case Presentation and Clinical Review
- Species:
- dog
Plain-English summary
A 12-year-old male Beagle was brought in for multiple soft lumps on his skin that had been growing slowly all over his body. After several tests, including skin samples and imaging, the vet found that the lumps were likely a type of B-cell lymphoma with plasmablastic features, but a clear diagnosis was difficult. The dog was treated with a chemotherapy protocol and initially went into complete remission, but unfortunately, the lumps returned about four months later. This case highlights the challenges in diagnosing and treating certain skin cancers in dogs, and more research is needed to better understand these conditions.
People also search for: Beagle skin lumps treatment · dog lymphoma symptoms · chemotherapy for dog cancer
Abstract
Cutaneous lymphoid neoplasms and cutaneous plasmacytosis are rare in the dog; in human and in veterinary medicine, these have many clinical, cytological, histological, and phenotypic similarities, and a diagnosis of certainty is not easy. The aim of this study is to describe a case of cutaneous non epitheliotropic B-cell lymphoma (CNEBL) with plasmablastic differentiation vs. multiple cutaneous plasmacytosis (CP) in a dog, since the scarce bibliographic data on these topics. A 12-year-old male Beagle dog was presented for multiple, nodular, cutaneous, and subcutaneous, indolent masses disseminated on the whole body. Cytological, histological, flow cytometric, and immunohistochemical examinations, as well as complete radiographic evaluation, echocardiography, and abdominal ultrasound were performed. Cytology, histopathology, flow cytometric, and immunohistochemical examination, performed on the skin lesions, revealed a B-cell phenotype with plasmablastic differentiation. Nevertheless, a final diagnosis could not be achieved and it was categorized as a case of borderline CNEBL with plasmablastic differentiation versus CP. The dog was treated with a COP chemotherapeutic protocol. Total remission was obtained and relapse occurred 120 days later. To our knowledge, specific markers are actually unavailable to certainly differentiate CNEBL and CP in the dog and future studies are needed to improve knowledge on these pathologies in veterinary medicine, since prognosis and therapy are different.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/vetsci8120317