Peer-reviewed veterinary case report
Dog with fast-growing skin lymphoma and recurring nodules
By Ellen Cristina Siepmann et al.·Published in Medicina Veterinária·2020·Universidade Federal do Paraná, BR
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Nonepitheliotropic lymphoma in a dog: case report
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed female dog had ulcerated and rapidly growing skin nodules, which led her owner to seek veterinary care. Initial tests suggested a type of skin tumor, and the nodules were surgically removed. Unfortunately, new lesions appeared after a year, prompting another surgery. Further testing revealed that the dog had nonepitheliotropic cutaneous T-cell lymphoma, a rare form of skin cancer. While the exact cause is unclear, chronic skin inflammation may have contributed to the condition. The dog received appropriate treatment, but ongoing monitoring is essential for managing this type of lymphoma.
People also search for: dog skin lumps treatment · mixed-breed dog skin cancer · nonepitheliotropic lymphoma in dogs
Abstract
Cutaneous lymphoma is an uncommon neoplasm in dogs and Boxer, Shih Tzu, Cocker Spaniel, Basset Hound and Golden Retriever are predisposed breeds. This report describes the case of a 5-year-old mixed-breed female dog presenting ulcerated and fast-growing skin nodules. Initial cytology revealed a poorly differentiated round cell neoplasm. Excision of nodules was performed due to the emergence of new lesions. Histopathological examination was suggestive of histiocytoma. The lesions recurred after one year, and a surgical excision of nodules was performed. An immunohistochemical examination was carried out to refine the diagnosis, revealing positivity for CD3 markers in neoplastic cells and for HLA-DR in neoplastic lymphoid and reactive histiocytic cells; these findings, coupled with the morphological findings, were compatible with nonepitheliotropic cutaneous T-cell lymphoma. Its etiology has not yet been fully elucidated; however, recurrent skin inflammation may be a predisposing factor, which leads to chronic lymphocytic proliferation. Cutaneous lymphoma (CL) causes nonspecific lesions and its classification as epitheliotropic and nonepitheliotropic (NEL) throughout cutaneous signs is difficult, with NEL being the least described form. Animals affected by this form of lymphoma have lymphadenomegaly, firm and multiple nodules that can extend from the dermis to the subcutaneous layer, alopecic and/or ulcerated, often in chest, head and extremities, with rapid progression, which was compatible with the present case. Definitive diagnosis of CL is obtained through histopathology and immunohistochemistry. The aim is to report a case of nonepitheliotropic cutaneous lymphoma in a dog, with emphasis on its clinical, histopathological, and immunohistochemical aspects.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →