Peer-reviewed veterinary case report
Oral canine parvovirus vaccine triggers immune response in puppies
By Cavalli, A et al.·Published in Vaccine·2020·Department of Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: Oral administration of modified live canine parvovirus type 2b induces systemic immune response.
- Species:
- dog
Plain-English summary
A group of 14 six-week-old puppies were given an oral vaccine for canine parvovirus (CPV-2b) to see if it could work despite the presence of antibodies from their mothers that usually block vaccinations. After the first dose, 13 of the puppies showed a positive immune response, and one more responded after the second dose. This suggests that the oral vaccine can effectively help puppies build immunity against CPV-2, even when maternal antibodies are still present.
People also search for: puppy parvovirus vaccine · oral vaccine for dogs · canine parvovirus immunity in puppies
Abstract
Different strategies have been proposed to overcome maternally derived antibody (MDA) interference with canine parvovirus type 2 (CPV-2) immunisation, including intranasal vaccination, which presents some practical limitations. In the present study, the results of the oral administration of a commercial CPV-2b modified live virus (MLV) vaccine in pups with MDA are reported. The CPV-2b vaccine was orally administered to 14 6-week-old pups with a bait. Blood samples and rectal swabs were collected at different days post-vaccination (dpv) to determine CPV-2 antibody titres and DNA loads. Thirteen pups were positive to serological and virological tests after the first vaccination and one pup became positive after the second vaccine administration. The findings of this study suggest that systemic immunity against CPV-2 may be achieved by the use of an MLV CPV-2b vaccine administered orally even in the presence of MDA titres that usually interfere with vaccination.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31628031/