Peer-reviewed veterinary case report
Oral administration of undenatured type II collagen significantly inhibits arthritis-associated pain signal in a mouse model of collagen antibody-induced arthritis and meniscus removal.
- Journal:
- Journal of pharmacological sciences
- Year:
- 2025
- Authors:
- Yasuda, Ibuki et al.
- Affiliation:
- School of Veterinary Medicine · Japan
Abstract
Osteoarthritis (OA) is joint pain caused by persistent low-grade inflammation, and is characterized by bone remodeling, synovitis, and articular cartilage degeneration. This study focused on undenatured type II collagen (UC-II®) and examined its influence on OA-associated pain. The increased Cainflux to typical nociceptive receptors TRPA1 and TRPV1 in the peripheral neurons of dorsal root ganglia was significantly inhibited by UC-II® treatment and similar inhibitory patterns were confirmed in vivo pain behavior tests in a mouse model of arthritis. Our findings suggest the effectiveness of UC-II® on OA-associated pain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40544000/