Peer-reviewed veterinary case report
Dog with rare oral melanoma tumor that makes bone
By Chénier, S & Doré, M·Published in Veterinary pathology·1999·View original on PubMed →
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Original publication title: Oral malignant melanoma with osteoid formation in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old Miniature Dachshund was diagnosed with a malignant melanoma in its mouth, which is a type of cancer that can occur in dogs. The tumor was a hard, round mass about 1 cm wide, and it had unusual bone-like features. After the tumor was surgically removed, it unfortunately came back three months later. This case is notable because it’s the first time this specific type of melanoma with bone formation has been reported in dogs.
People also search for: dog oral melanoma treatment · Miniature Dachshund mouth tumor · dog cancer recurrence signs
Abstract
Melanomas are the most frequent malignant neoplasms of the oral cavity of dogs. Osteogenic melanoma is a rare variant of melanoma that has been described in humans but not in animals. We describe a case of malignant melanoma with bone production affecting the gingiva of a 12-year-old Miniature Dachshund dog. The tumor was a round, lightly pigmented mass that measured 1 cm in diameter and was hard to cut. Histologically, the tumor was composed of nests and lobules of anaplastic, round, melanin-containing cells supported by a stroma displaying abundant osteoid matrix. Many of the neoplastic melanocytic cells were in close contact with the osteoid trabeculae. Immunohistochemical tests revealed that the neoplastic cells were immunoreactive for S-100 and vimentin and showed no staining with cytokeratin. The animal had a local recurrence of the tumor 3 months after the initial excision. This is the first case of malignant melanoma with osteoid formation reported in animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9921760/