Peer-reviewed veterinary case report
Electrochemotherapy for treating dog mouth cancer using oral mucosa
By Suzuki, Daniela O H et al.·Published in Artificial organs·2018·Institute of Biomedical Engineering, Brazil·View original on PubMed →
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Original publication title: Oral Mucosa Model for Electrochemotherapy Treatment of Dog Mouth Cancer: Ex Vivo, In Silico, and In Vivo Experiments.
- Species:
- dog
Plain-English summary
A dog with mouth cancer, specifically a spontaneous oral melanoma, was treated using a method called electrochemotherapy (EQT), which uses electric fields to help cancer-fighting drugs enter tumor cells more effectively. Researchers created a model to understand how the dog's mouth tissue responds to this treatment, which is important because each dog's anatomy can vary significantly. By optimizing the treatment plan based on these models, they aim to improve the effectiveness of EQT for oral tumors. This approach could lead to better outcomes for dogs suffering from mouth cancer.
People also search for: dog mouth cancer treatment · electrochemotherapy for dogs · canine oral melanoma care
Abstract
Electrochemotherapy (EQT) is a local cancer treatment well established to cutaneous and subcutaneous tumors. Electric fields are applied to biological tissue in order to improve membrane permeability for cytotoxic drugs. This phenomenon is called electroporation or electropermeabilization. Studies have reported that tissue conductivity is electric field dependent. Electroporation numerical models of biological tissues are essential in treatment planning. Tumors of the mouth are very common in dogs. Inadequate EQT treatment of oral tumor may be caused by significant anatomic variations between dogs and tumor position. Numerical models of oral mucosa and tumor allow the treatment planning and optimization of electrodes for each patient. In this work, oral mucosa conductivity during electroporation was characterized by measuring applied voltage and current of ex vivo rats. This electroporation model was used with a spontaneous canine oral melanoma. The model outcomes of oral tumor EQT is applied in different parts of the oral cavity including near bones and the hard palate. The numerical modeling for treatment planning will help the development of new electrodes and increase the EQT effectiveness.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29027689/