Peer-reviewed veterinary case report
Oral papillomas on tongue linked to cat papillomavirus type 1
By Munday, J S et al.·Published in Veterinary pathology·2015·Institute of Veterinary·View original on PubMed →
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Original publication title: Oral Papillomas Associated With Felis catus Papillomavirus Type 1 in 2 Domestic Cats.
- Species:
- cat
Plain-English summary
Two 13-year-old domestic cats were found to have small raised lesions on the underside of their tongues. These lesions were identified as papillomas, which are growths caused by a specific virus known as Felis catus papillomavirus type 1. In one cat, the lesions disappeared within three months, while the other cat still had visible lesions four months after diagnosis. This case highlights the connection between these tongue lesions and the papillomavirus in cats.
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Abstract
Multiple small sessile raised lesions were detected on the ventral surface of the tongue in two 13-year-old domestic cats. The lesions were incidental in both cats. Lesions from both cats appeared histologically as well-demarcated foci of markedly thickened folded epithelium that formed keratin-filled shallow cuplike structures. Large keratinocytes that contained a swollen nucleus surrounded by a clear cytoplasmic halo (koilocytes) were common, suggesting a diagnosis of a papillomavirus-induced papillomas, and papillomavirus antigen was demonstrated by immunohistochemistry. The papillomas exhibited diffuse intense cytoplasmic and nuclear immunoreactivity against cyclin-dependent kinase inhibitor 2A protein (also known as p16 or INK4a protein). Felis catus papillomavirus type 1 DNA sequences were amplified from both papillomas. The papillomas resolved in 1 cat within 3 months of diagnosis, while the papillomas were still visible 4 months after diagnosis in the other cat. This is the first evidence that these papillomas are caused by F. catus papillomavirus type 1.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25572261/