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Peer-reviewed veterinary case report

Oral Squamomelanocytic Tumour in a Dog: a Unique Biphasic Cancer.

Journal:
Journal of comparative pathology
Year:
2016
Authors:
Muscatello, L V et al.
Affiliation:
Department of Veterinary Medical Sciences · Italy
Species:
dog

Abstract

In human medicine, squamomelanocytic tumour is a malignant cutaneous neoplasm composed of closely intermingled neoplastic squamous cells and melanocytes. A multinodular gingival tumour in a 16-year-old, mixed breed neutered female dog was examined microscopically. Two populations of neoplastic cells, melanocytic and squamous epithelial cells were intermingled. The melanocytic cells were melan-A positive and cytokeratin AE1-AE3 negative and the squamous component was cytokeratin AE1-AE3 positive and melan-A negative. Bovine papillomavirus was not identified by immunohistochemistry or polymerase chain reaction. A diagnosis of squamomelanocytic tumour was made.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/26805740/