Peer-reviewed veterinary case report
Survival and outlook for dogs with splenic lymphoma after spleen
By van Stee, Lucinda L. et al.·Published in Veterinary Surgery·2015·Department of Clinical Sciences of Companion Animals Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands, Netherlands·View original on Crossref →
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Original publication title: Outcome and Prognostic Factors for Canine Splenic Lymphoma Treated by Splenectomy (1995–2011)
- Species:
- dog
Plain-English summary
A group of 28 dogs with splenic lymphoma (a type of cancer affecting the spleen) underwent surgery to remove the spleen, known as splenectomy. Many of these dogs showed symptoms like a swollen abdomen, tiredness, and loss of appetite. After surgery, about 59% of the dogs survived for at least a year, especially those whose cancer was limited to the spleen. Unfortunately, adding chemotherapy did not seem to help improve their survival. Overall, the surgery was effective for dogs with localized disease, but those with more severe symptoms had a poorer outlook.
People also search for: dog splenic lymphoma treatment · dog spleen surgery recovery · signs of dog lymphoma
Abstract
ObjectiveTo assess the outcome of canine splenic lymphoma treated with splenectomy and to evaluate prognostic factors, including involvement of other sites, adjuvant chemotherapy, and the effect of World Health Organization (WHO) histological classification of canine malignant lymphoma.DesignMulti‐institutional, retrospective study.AnimalsClient‐owned dogs (n = 28).MethodsMedical records (1995–2011) of dogs with a histological diagnosis of splenic lymphoma and treated by splenectomy submitted by Veterinary Society of Surgical Oncology members were reviewed. Included were dogs treated with or without adjuvant therapy. Overall survival, disease‐free interval, and cause of death were determined. Prognostic factors and the WHO histological classification of canine malignant lymphoma were evaluated with respect to outcome.ResultsDogs with splenic lymphoma treated by splenectomy had a 1‐year survival rate of 58.8%, after which no animals died of their disease. B cell lymphoma held a better prognosis for survival than other variants of splenic lymphoma. Marginal zone lymphoma and mantle cell lymphoma were the most common B cell lymphoma subtypes in our study. Hemoabdomen and clinical signs related to splenic lymphoma, including abdominal distention, lethargy, and anorexia, were poor prognostic indicators, whereas disease confined to the spleen was a positive prognostic indicator. Pre‐ or postoperative adjuvant chemotherapy did not provide a survival benefit.ConclusionBased on our sample population, splenectomy alone was an effective treatment for splenic lymphoma in cases with disease confined to the spleen. Chemotherapy may not improve survival in cases of lymphoma restricted to the spleen.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vsu.12405