Peer-reviewed veterinary case report
Radiation treatment results for dogs with infiltrative lipoma tumors
By Matsuyama, Arata et al.·Published in Veterinary and comparative oncology·2025·Department of Small Animal Clinical Sciences, Canada·View original on PubMed →
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Original publication title: Outcome and Prognostic Factors of Dogs Treated for Infiltrative Lipoma Undergoing Radiation Therapy: A Retrospective Multi-Institutional Study of 29 Cases.
- Species:
- dog
Plain-English summary
A group of dogs with infiltrative lipomas, which are invasive tumors, underwent radiation therapy to see how effective it would be. The study included 29 dogs, and they received a median radiation dose of 51 Gy. Most dogs had good outcomes, with a median survival time of about 1483 days, although some experienced disease progression, particularly those that received lower doses. The results suggest that higher doses of radiation may lead to better control of these tumors, making radiation a viable option for dogs with these types of lipomas.
People also search for: dog infiltrative lipoma treatment · radiation therapy for dog tumors · dog tumor survival rates
Abstract
Canine infiltrative lipomas are localised and invasive tumours that are commonly treated with surgery and/or radiation therapy (RT). There is limited efficacy data for treatment of infiltrative lipomas, and optimal fractionation strategies remain unclear. We retrospectively assessed the outcomes and prognostic factors in a cohort of dogs that underwent intensity modulated or three-dimensional conformal RT for infiltrative lipoma. Twenty-nine dogs were included from four academic institutions. The median total radiation dose prescribed and delivered was 51 Gy (range = 20-57 Gy). Dose per fraction ranged from 2.4 to 4.2 Gy, with a median of 3 Gy. Median progression-free survival (PFS) was 1483 days; the median overall survival (OS) was 1483 days. Disease progression was documented in four dogs (14%), all of which received less than 51 Gy (range = 20-50 Gy). Grade V adverse events (AEs) or secondary malignancies were recorded in six dogs (21%; two bones, one skin, one lungs, one urethra and one small intestine AE); assigned attribution was definite (n = 1), probable (n = 2), possible (n = 2) and unlikely (n = 1). Gross tumour volume (GTV) was prognostic for PFS (p < 0.01) while both GTV (p < 0.01) and total radiation dose (p < 0.01) were prognostic for OS (p < 0.01). The number of surgeries and tumour location were not associated with PFS or OS. These findings support the use of RT for long-term local control for unresectable or incompletely excised canine infiltrative lipomas. A higher total radiation dose may result in better long-term local disease control.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40364755/