Peer-reviewed veterinary case report
Radiation treatment results for infiltrative lipomas in 21 dogs
By Hauser, Adam et al.·Published in Veterinary and comparative oncology·2024·College of Veterinary Medicine and Biomedical Sciences, United States·View original on PubMed →
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Original publication title: A Retrospective Study Evaluating the Outcomes of Conventionally Fractionated Radiation Therapy as a Treatment for Infiltrative Lipomas in Twenty-One Dogs.
- Species:
- dog
Plain-English summary
A group of 21 dogs with infiltrative lipomas, which are a type of aggressive fatty tumor, were treated with radiation therapy after previous surgeries. About half of the dogs showed no regrowth of the tumors after treatment, while others had stable disease or some regrowth. The dogs that had only one prior surgery before radiation tended to have better outcomes compared to those with multiple surgeries. Overall, the dogs had a median survival time of about 1,694 days, and many were still alive at the time of the study. This suggests that radiation therapy can be an effective option for managing these tumors in dogs.
People also search for: dog infiltrative lipoma treatment · radiation therapy for dog tumors · dog fatty tumor survival rate
Abstract
Infiltrative lipomas represent a subcategorisation of rarer, potentially more aggressive, lipoma-related neoplasms. Twenty-one dogs treated with conventionally fractionated radiotherapy (CFRT) for infiltrative lipomas were included in this retrospective study. One patient had no prior surgical excision, 11 patients had one prior surgery and 9 patients had two or more surgeries prior to CFRT. Five patients (24%) had microscopic disease and 16 patients (76%) had macroscopic disease prior to treatment. A complete response or no regrowth was seen in 10 patients (48%), stable disease in 6 patients (29%) and progressive disease or regrowth in 5 patients (24%). Response to treatment of macroscopic tumours was significantly different between dogs that had one prior surgery versus two or more (p = 0.01). Dogs with a single surgery were most likely to result in stable disease compared with dogs with two or more surgeries resulting in a complete response. The dog without surgery developed progressive disease at 211 days, dogs with one surgery had a median progression or recurrence at 1369 days and dogs with two or more surgeries developed progression or recurrence at 826 days (p = 0.04). Twelve dogs were alive at the time of analysis. Overall median survival time (MST) was 1694 days. The prior number of surgeries did not significantly affect MST. While survival time is comparable to previous reports, the number of patients with progressive disease or recurrence of previous microscopic disease requires more investigation into the most appropriate protocol, dose and treated field size.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39288821/