Peer-reviewed veterinary case report
Biomarkers NGAL and TIMP-2 predict kidney injury outcomes
By Dorn, Elisabeth et al.Ā·Published in Journal of veterinary internal medicineĀ·2025Ā·Small Animal DepartmentĀ·View original on PubMed ā
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Original publication title: Outcome in Critically Ill Dogs and Dogs With Acute Kidney Injury Based on Neutrophil Gelatinase-Associated Lipocalin and Tissue Inhibitor of Metalloproteinase-2.
- Species:
- dog
Plain-English summary
A group of critically ill dogs and dogs with acute kidney injury (AKI) were tested for specific markers in their blood and urine to see if these could predict their chances of survival. The study found that dogs with higher levels of certain markers (uNGAL and sNGAL) at the time of admission were less likely to survive. Specifically, non-surviving dogs had significantly higher levels of these markers compared to those that did survive. This suggests that measuring these markers could help veterinarians assess the severity of kidney issues and the likelihood of recovery in sick dogs.
People also search for: dog acute kidney injury symptoms Ā· dog survival rates with kidney disease Ā· what does high uNGAL mean in dogs
Abstract
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) and tissue inhibitor of metalloproteinase-2 (TIMP-2) have potential as early biomarkers for acute kidney injury (AKI) in dogs. OBJECTIVES: Assess whether NGAL and TIMP-2 at admission (T0) and 24 h later (T1) identify survival in critically ill (CI) and AKI dogs, development of hospital-acquired AKI in CI dogs, and development of chronic kidney disease (CKD) in AKI dogs after 3 months. ANIMALS: Sixty-two client-owned dogs: 10 healthy, 24 with AKI, and 28 CI. METHODS: Prospective study with blood and urine samples collected at T0, T1, and up to 1 week in CI dogs, 1 month in healthy dogs, and 3 months in AKI dogs. Serum and urinary NGAL (sNGAL; uNGAL) and urinary TIMP-2 (uTIMP-2) were measured using validated ELISA kits. RESULTS: Dogs with AKI that did not survive had significantly higher uNGAL concentrations and u/sNGAL ratios at T0 compared with survivors (p = 0.05, n = 23; and p = 0.03, n = 21, respectively). In CI dogs, sNGAL was significantly higher in non-survivors at T0 and T1 compared with survivors (p = 0.02, n = 26; and p = 0.003, n = 26, respectively). At T0, normalized urinary tissue inhibitor of metalloproteinase-2 (uTIMP-2) was significantly higher in non-survivor CI dogs compared with survivors (p = 0.04, n = 25). No significant differences were found for the other variables. CONCLUSIONS AND CLINICAL RELEVANCE: In AKI dogs, uNGAL and u/sNGAL at T0, and in CI dogs, sNGAL at T0 and T1 and uTIMP-2 at T0, were potential predictors of survival.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40008829/