Peer-reviewed veterinary case report
Survival and treatment results for cats with low-grade lymphoma
By Kiselow, Michael A et al.·Published in Journal of the American Veterinary Medical Association·2008·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005).
- Species:
- cat
Plain-English summary
A group of 41 cats diagnosed with low-grade lymphocytic lymphoma, which often caused symptoms like weight loss, vomiting, and diarrhea, were treated with prednisone and chlorambucil. Most cats responded well to the treatment, with 56% achieving complete remission and 39% showing partial improvement. The average survival time for these cats was about 704 days, and those who had a complete response enjoyed a longer remission period compared to those with partial responses. Overall, the treatment was effective for many cats, providing a good quality of life for a significant duration.
People also search for: cat lymphoma treatment · symptoms of lymphoma in cats · prednisone for cats with cancer
Abstract
OBJECTIVE: To evaluate factors associated with response to treatment, remission duration, and survival in cats with low-grade lymphoma affecting various organ systems. DESIGN: Retrospective case series. SAMPLE POPULATION: 41 cats with histologically confirmed low-grade lymphocytic lymphoma. PROCEDURES: Medical records and biopsy specimens of cats with histologically confirmed low-grade lymphocytic lymphoma of various organ systems treated with prednisone and chlorambucil between 1995 and 2005 were reviewed. The Kaplan-Meier method was used to estimate remission duration and survival. Factors potentially associated with prognosis were compared. RESULTS: Common clinical signs were weight loss (83%), vomiting (73%), anorexia (66%), and diarrhea (58%). Seventy-eight percent of cats tested had low serum cobalamin concentrations. Lymphoma was confined to the gastrointestinal tract in 68% of cats. Fifty-six percent of cats achieved a complete response to treatment, and 39% achieved a partial response. Five percent of cats had no response. No association was found between any risk factors (including anatomic site) and response to treatment. Partial response was associated with shorter remission duration, compared with complete response; median remission duration was 428 days for cats achieving a partial response, compared with 897 days for cats achieving a complete response. No other factors were associated with remission duration. Overall median survival time was 704 days. No factors were significantly associated with survival time. CONCLUSIONS AND CLINICAL RELEVANCE: Most cats with lymphocytic lymphoma responded to treatment with prednisone and chlorambucil, and most factors evaluated were not associated with outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18241108/