Peer-reviewed veterinary case report
Oxidative red blood cell damage associated with propofol and intravenous lipid emulsion therapy in a dog treated for 5-fluorouracil toxicosis.
- Journal:
- Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
- Year:
- 2020
- Authors:
- Romans, Cory W et al.
- Affiliation:
- Veterinary Emergency Service
- Species:
- dog
Abstract
OBJECTIVE: To describe the first documented case of oxidant-induced anemia in a dog associated with propofol and IV lipid emulsion (IVLE) treatment for 5-fluorouracil (5-FU) toxicosis. CASE SUMMARY: A 2-year-old male intact mixed breed dog was presented for evaluation after ingestion of 5% 5-FU cream. Refractory reactive seizures rapidly developed, and treatment with benzodiazepines, propofol, levetiracetam, and IVLE was initiated. The dog was euthanized due to development of marked oxidant-induced anemia. NEW INFORMATION PROVIDED: This report documents the first instance of oxidant-induced anemia in the dog, associated with propofol and IVLE infusion therapy prescribed for treatment of 5-FU toxicosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32407575/