Peer-reviewed veterinary case report
Dog developed anemia after propofol and lipid treatment
By Romans, Cory W et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2020·Veterinary Emergency Service·View original on PubMed →
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Original publication title: Oxidative red blood cell damage associated with propofol and intravenous lipid emulsion therapy in a dog treated for 5-fluorouracil toxicosis.
- Species:
- dog
Plain-English summary
A 2-year-old male mixed breed dog developed severe seizures after accidentally ingesting a toxic cream containing 5-fluorouracil (5-FU). Despite treatment with several medications, including propofol and intravenous lipid emulsion, the dog suffered from a serious condition called oxidant-induced anemia, which led to its euthanasia. This case highlights the potential risks associated with certain treatments in dogs exposed to specific toxins.
People also search for: dog seizures after eating 5-FU cream · propofol side effects in dogs · treatment for dog toxic exposure
Abstract
OBJECTIVE: To describe the first documented case of oxidant-induced anemia in a dog associated with propofol and IV lipid emulsion (IVLE) treatment for 5-fluorouracil (5-FU) toxicosis. CASE SUMMARY: A 2-year-old male intact mixed breed dog was presented for evaluation after ingestion of 5% 5-FU cream. Refractory reactive seizures rapidly developed, and treatment with benzodiazepines, propofol, levetiracetam, and IVLE was initiated. The dog was euthanized due to development of marked oxidant-induced anemia. NEW INFORMATION PROVIDED: This report documents the first instance of oxidant-induced anemia in the dog, associated with propofol and IVLE infusion therapy prescribed for treatment of 5-FU toxicosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32407575/