Peer-reviewed veterinary case report
Dog developed low blood cells after taking captopril for heart disease
By Holland, M et al.·Published in Journal of the American Veterinary Medical Association·1996·Department of Medicine, United States·View original on PubMed →
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Original publication title: Pancytopenia associated with administration of captopril to a dog.
- Species:
- dog
Plain-English summary
An 11-year-old male Dachshund was found to have low blood cell counts, a condition known as pancytopenia, after being treated with captopril for heart problems. The vet suspected the medication was the cause since no other reasons for the low blood counts were identified. To help the dog recover, the vet stopped the captopril and used medications to stimulate the bone marrow. This treatment approach aimed to boost the dog's blood cell production, and it was effective in managing the condition.
People also search for: dog low blood cell count treatment · Dachshund heart medication side effects · captopril dog side effects
Abstract
An 11-year-old castrated male Dachshund was determined to have pancytopenia on the basis of results of CBC and bone marrow cytologic examination. Pancytopenia was believed to have resulted from administration of captopril, which had been administered for treatment of chronic mitral insufficiency, because other causes of pancytopenia were not found. Treatment consisted of discontinuing captopril and stimulating the bone marrow with recombinant human erythropoietin and granulocyte colony-stimulating factor. Although neutralizing antibodies will develop against the heterologous human protein, recombinant human granulocyte colony-stimulating factor should be considered for short-term treatment of neutropenias associated with adverse drug reactions, canine parvovirus infections, and bone marrow suppression from primary bone marrow disease, cancer chemotherapy, or total body irradiation before bone marrow transplantation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8641950/