Peer-reviewed veterinary case report
Papillary ductal adenocarcinoma in the mammary glands of two horses.
- Journal:
- The Veterinary record
- Year:
- 1996
- Authors:
- Reppas, G P et al.
- Affiliation:
- Department of Animal Health · United Kingdom
- Species:
- horse
Plain-English summary
In this study, two horses were found to have unusual growths in their mammary glands, which can sometimes be mistaken for an infection called mastitis. Both horses had ongoing discharge from their mammary glands, and tests showed that the growths were papillary ductal adenocarcinomas, a type of cancer. Further tests were done to see if hormone treatments could help alongside surgery, but the results showed that the tumors did not have the hormone receptors for estrogen or progesterone. This means that hormonal treatment would not be an option for these horses.
Abstract
Mammary gland neoplasms in horses are uncommon and may initially be confused with mastitis. Masses from the mammary glands of two horses with chronic discharges were examined by cytology and histopathology. Both masses were diagnosed as papillary ductal adenocarcinomas with extensive intraductal and intralobular involvement and only focal infiltration of the adjacent stroma. Complementary immunohistochemical studies were made of both fresh and formalin-fixed tumour tissue, and attempts were made to assess the steroid receptor status of fresh tissue biochemically to assess the possibility of hormonal treatment as an adjunct to surgery. The results of these tests for oestrogen and progesterone receptors were negative.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8761975/