Peer-reviewed veterinary case report
Invasive ductal carcinoma of the mammary gland in a mare.
- Journal:
- Veterinary pathology
- Year:
- 2003
- Authors:
- Hirayama, K et al.
- Species:
- horse
Plain-English summary
A 21-year-old thoroughbred mare had a large mass in her mammary gland measuring about 14 inches long. Unfortunately, the cancer had spread to her kidneys, lungs, muscles, and nearby lymph nodes. A closer examination of the tumor showed it was a type of breast cancer called invasive ductal carcinoma, which had affected the surrounding tissues as well. Despite the detailed analysis, the prognosis for the mare was not mentioned, but the presence of multiple metastases indicates a serious condition.
Abstract
A 21-year-old thoroughbred mare had a 35 x 14 x 10 cm mass involving the mammary gland. Metastases were found in the kidneys, lungs, skeletal muscles, and regional lymph nodes. Histopathologic examination of the tumor revealed a ductal solid carcinoma with extensive intraductal and intralobular involvement and focal infiltration of the adjacent stroma. The intralobular neoplasms were divided into irregularly shaped islands and sheets of polygonal and spindle-shaped epithelial cells by thick or thin fibrous connective tissue bundles. The neoplastic cells had a small or moderate amount of cytoplasm that stained faintly with eosin and round or oval hyperchromatic nuclei. Immunohistochemically, the neoplastic cells were strongly positive for Lu-5, weakly positive for AE1/AE3, vimentin, and glial fibrillary acidic protein, and negative for cytokeratin 8, cytokeratin 14, alpha-smooth muscle actin, calponin, and S100. The neoplasm was diagnosed as an invasive ductal carcinoma of the mammary gland with multiple metastases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/12627717/