Peer-reviewed veterinary case report
Dog with mouth and skin ulcers caused by paraneoplastic pemphigus
By Lemmens et al.·Published in Veterinary Dermatology·1998·View original on Crossref →
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Original publication title: Paraneoplastic pemphigus in a dog
- Species:
- dog
Plain-English summary
A 7-year-old female Bouvier was brought in with severe mouth sores that got worse after starting treatment with a common antibiotic. Soon after, she developed painful blisters and ulcers on her ears, nose, around her eyes, and at her nails. Despite various treatments, her condition continued to worsen, and she was ultimately euthanized. A post-mortem exam revealed she had thymic lymphoma, a type of cancer, and tests showed she had a serious skin disease called pemphigus vulgaris, which causes the immune system to attack the skin.
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Abstract
This report presents a case of paraneoplastic pemphigus in a 7‐year‐old female Bouvier. The dog initially showed extensive oral ulcerations that exacerbated upon treatment with trimethoprim‐sulfadiazine. Subsequently, the dog developed vesiculobullous and ulcerative lesions on the ear margins, the nose, periocular, and at the nail beds. Due to complete therapy resistance and a deteriorating general condition, the dog was euthanized. During post‐mortem examination a thymic lymphoma was found. While an early biopsy of the oral cavity revealed features of erythema multiforme, skin lesions at necropsy were typical of pemphigus vulgaris. Indirect immunofluorescence of patient serum revealed an antikeratinocyte membrane pattern typical for pemphigus. The serum was also positive on bovine bladder epithelium. In a Western blot, autoantibodies to a 210 and a 190 kDa protein were detected.
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Search related cases →Original publication on Crossref: https://doi.org/10.1046/j.1365-3164.1998.00095.x