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Peer-reviewed veterinary case report

Partial deficiency of antidiuretic hormone in a cat.

Journal:
Journal of the American Veterinary Medical Association
Year:
1977
Authors:
Rogers, W A et al.
Species:
cat

Plain-English summary

A 1 1/2-year-old male Abyssinian cat developed a significant increase in drinking and urination after experiencing trauma. The veterinarian suspected diabetes insipidus, a condition where the body doesn't properly regulate water balance, and noticed improvement in the cat's symptoms after giving a hormone called vasopressin. However, when the cat was given a saline solution, it stopped urinating, suggesting that some antidiuretic hormone (which helps the body retain water) was still working. The cat's excessive drinking and urination completely stopped after starting treatment with a medication called chlorpropamide, indicating that there was a partial deficiency of antidiuretic hormone. Overall, the treatment was effective in resolving the cat's symptoms.

Abstract

Marked polydipsia and polyuria developed subsequent to trauma in a 1 1/2-year-old male Abyssinian cat. Diabetes insipidus was suspected, inasmuch as intramuscualr vasopressin administration resulted in amelioration of polydipsia and polyuria. However, hypertonic (3%) saline solution given intravneously resulted in anuria, an indication of antidiuretic hormone activity. Polyuria and polydipsia were abolished by oral chlorpropamide therapy, which was indirect evidence for partial deficiency of antidiuretic hormone.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/557470/