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Peer-reviewed veterinary case report

Trauma-induced central diabetes insipidus in a cat.

Journal:
Australian veterinary journal
Year:
2008
Authors:
Campbell, F E & Bredhauer, B
Affiliation:
Veterinary Teaching Hospital · Australia
Species:
cat

Plain-English summary

A 1-year-old neutered male domestic shorthair cat had been drinking a lot of water for four weeks after falling from a height of eight meters. The vet suspected he had a condition called central diabetes insipidus, which affects the body's ability to concentrate urine, based on tests that showed diluted urine and normal blood work. After confirming the diagnosis with a specific hormone treatment, the cat initially didn't improve when the hormone was given in one way, but he did get better when it was given under the skin. Now, 17 months later, the cat is doing well and only needs this treatment twice a day to keep his water intake normal.

Abstract

A 1-year-old neutered male domestic shorthair cat presented with a 4-week history of polydipsia that began immediately after an 8 m fall. Trauma-induced central diabetes insipidus was suspected on the basis of the identification of hyposthenuria, normal haematology and serum biochemistry profile and unremarkable abdominal ultrasound examination. Failure to concentrate urine with water deprivation followed by production of hypersthenuric urine with administration of the synthetic antidiuretic hormone, Damino-8-D-arginine vasopressin (DDAVP), confirmed the diagnosis of central diabetes insipidus. Treatment via conjunctival administration of DDAVP failed to attenuate the polydipsia, however, resolution of polydipsia was achieved with subcutaneous administration of DDAVP and the cat remains eudipsic with twice daily subcutaneous DDAVP administration 17 months after diagnosis.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/18304048/