Peer-reviewed veterinary case report
Subdural histiocytic sarcoma brain tumors in Pembroke Welsh Corgis
By Ide, Tetsuya et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs.
- Species:
- dog
Plain-English summary
A 7-year-old Pembroke Welsh Corgi was diagnosed with a subdural histiocytic sarcoma, a type of tumor located in the brain. The dog showed signs of neurological issues due to the mass pressing on the brain. After examination, the tumor was found to have specific characteristics that helped the veterinarians understand its nature. Unfortunately, the study did not provide information on treatment outcomes for these cases, but it highlights the importance of recognizing this type of tumor in dogs, especially in certain breeds.
People also search for: dog brain tumor symptoms · Pembroke Welsh Corgi cancer · subdural histiocytic sarcoma treatment
Abstract
Subdural histiocytic sarcomas from 15 dogs (mean age 7.8 years) were histopathologically examined. Among the 15 dogs, there was a marked breed predominance (toward Pembroke Welsh Corgi dogs, 47%), but no gender predilection. Focal solitary subdural masses were detected in the cerebrum (12 cases) and spinal cord (1 case), whereas diffuse infiltrative lesions were observed in the cerebral leptomeninges in 2 cases. All neoplastic lesions had common histological features characterized by the proliferation of pleomorphic histiocytic cells combined with various inflammatory reactions. Multinucleated giant cells, phagocytosis, and atypical mitotic figures in the neoplastic cells were commonly observed. Most of the pleomorphic neoplastic cells in the present cases were immunopositive for monocytic, histiocytic, or both markers, such as human leukocyte antigen (HLA)-DR, ionized calcium-binding adaptor molecule 1 (Iba1), cluster of differentiation (CD)163, and CD204, except for the neoplastic cells in 2 focal and 2 diffuse histiocytic sarcomas. The findings suggest that differences in cell origin, molecular expression, or both patterns are responsible for the distribution patterns of canine subdural histiocytic sarcomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21217043/