Peer-reviewed veterinary case report
Primary splenic myxoid liposarcoma tumors in three dogs
By Forlani, A et al.Ā·Published in The veterinary quarterlyĀ·2015Ā·School of Veterinary Medicine, ItalyĀ·View original on PubMed ā
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Original publication title: Pathological characterization of primary splenic myxoid liposarcomas in three dogs.
- Species:
- dog
Plain-English summary
An 8-year-old male crossbreed, a 12-year-old female French bulldog, and an 11-year-old crossbreed were all diagnosed with splenic tumors and underwent surgery to remove their spleens. Unfortunately, all three dogs developed liver metastases (spread of cancer to the liver) after surgery and were euthanized. The first two dogs lived for about two months after surgery, while the French bulldog survived for 21 months. This type of tumor, called myxoid liposarcoma, is rare in dogs, and the prognosis is generally poor once it spreads.
People also search for: dog splenic tumor symptoms Ā· French bulldog cancer prognosis Ā· dog liver metastasis treatment
Abstract
Non-angiomatous-non-lymphomatous sarcomas (NANLs) represent 23%-34% of canine primary splenic sarcomas. Splenic liposarcomas account for 2%-6% of NANLs but myxoid variants are rarely reported and information on their behaviour is fragmentary. An 8-year-old male crossbreed (case 1), a 12-year-old female French bulldog (case 2), and an 11-year-old crossbreed (case 3) underwent splenectomy after the detection of a splenic nodule. Histology, histochemistry, immunohistochemistry, and transmission electron microscopy (TEM) were performed. Bundles of spindle-to-polygonal cells containing occasional cytoplasmic oil-red-O positive vacuoles embedded in an Alcian blue-positive extracellular matrix were observed. Aggregates of round cells were detected in cases 1 and 3. All tumours were vimentin positive and actin, desmin, Factor VIII, and S100 negative. The TEM evidenced different maturational stages of adipose cells (lipoblasts, intermediate, and undifferentiated). All the cases developed hepatic metastases and were euthanized. Disease free interval was 2 months in cases 1 and 3, and 21 months in case 2. The presence of a neoplastic embolus in case 1 and areas of round cell differentiation in cases 1 and 3 represented the sole prognostic indices.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25953196/