Peer-reviewed veterinary case report
Protein loss kidney disease like Alport syndrome in young Pyrenean
By Sugahara, Go et al.·Published in The Journal of veterinary medical science·2015·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Pathological features of proteinuric nephropathy resembling Alport syndrome in a young Pyrenean Mountain dog.
- Species:
- dog
Plain-English summary
A 9-month-old male Pyrenean Mountain dog was brought in with a kidney problem and severe protein in his urine. Tests showed damage to the kidney's filtering units, which suggested a hereditary kidney disease similar to Alport syndrome, a condition that affects collagen in the kidneys. The dog's condition indicated that injury to the kidney cells was likely causing the proteinuria. Unfortunately, the abstract does not provide information on the treatment or outcome for this dog.
People also search for: dog protein in urine · Pyrenean Mountain dog kidney disease · Alport syndrome in dogs
Abstract
The renal biopsy tissue from a 9-month-old, male Pyrenean Mountain dog with renal disorder and severe proteinuria was examined. Ultrastructural examination revealed multilaminar splitting and fragmentation of the glomerular basement membrane (GBM) and diffuse podocyte foot process effacement. Immunofluorescent staining for α(IV) chains revealed presence of α5(IV) and complete absence of α3(IV) and α4(IV) chains in the GBM. Immunohistochemistry also revealed decreased and altered expression of nephrin and podocin in the glomeruli compared with normal canine glomeruli. These results suggested that the glomerular disease of the present case might be consistent with canine hereditary nephropathy resembling human Alport syndrome caused by genetic defect of type IV collagen, and indicated possible contribution of podocyte injury to severe proteinuria in this case.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25892536/